Women's Health Medicine
Volume 3, Issue 5 , Pages 211-212, 1 September 2006

Dysfunctional uterine bleeding in adolescence

D Mazza MD MBBS FRACGP DRANZCOG Grad Dip Women's Health is Associate Professor in the Department of General Practice at Monash University, Melbourne, Austrialia

Abstract 

This paper assesses the basic steps of management and treatment of dysfunctional uterine bleeding (DUB) – the irregular bleeding arising from anovulation. After menarche, the hypothalamic-pituitary-ovarian axis can take several years to mature resulting in anovulatory and therefore irregular cycles. During an anovulatory cycle, the corpus luteum fails to form, causing failure of normal cyclical progesterone secretion. This results in continuous unopposed production of estradiol, stimulating overgrowth of the endometrium. Without progesterone, the endometrium grows thicker and thicker eventually outgrowing its blood supply, leading to necrosis. The end result is very heavy bleeding.

Keywords:  uterine bleeding , estradiol , progesterone , dysfunctional

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 This article has been reproduced from: Danielle Mazza. Women’s Health in General Practice. Oxford: Butterworth Heinemann, 2004.

PII: S1744-1870(06)70206-2

doi:10.1053/S1744-1870(06)70206-2

Women's Health Medicine
Volume 3, Issue 5 , Pages 211-212, 1 September 2006

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